Bilberry P.E. (plant extract)

History:Bilberry is a perennial shrub native to Northern Europe, Northern America, and Canada, and has been used in these areas for diabetes and eye disorders for a long history. It is also mentioned in many old texts in Buryatia, Europe and China as an herb valuable for it's powerful ability to correct many diseases of the digestive system, circulatory system and eyes.
Appearance: Deep purple powder

Specification:Anthocyanosides:>=10% or>=15% or>=40%

Functions:Bilberry is rich in anthocyanosides. Over 15 different anthocyanosides have been found in Bilberry. Anthocyanosides help to maintain the integrity of capillaries and to stabilize collagen. Anthocyanosides are also potent antioxidants. Numerous clinical studies have shown that Bilberry is effective in the treatment of circulation disorders, varicose veins, and other venous and arterial disorders.

The anthocyanosides protect veins and arteries by stabilizing the phospholipids of the endothelial cells and increasing the synthesis of collagen and mucopolysaccharides, which give the arterial walls their structural integrity. Anthocyanosides also prevent the aggregation and adherence of platelets to endothelial surfaces. Studies have also shown that Bilberry can act as a coadjutant in heme-ralopy and diabetic retinopathy by stimulating rhodopsin production.

1. Normalization of capillary permeability

Anthocyanosides has extremely strong "vitamin P" activity, which increase intracellular vitamin C levels and decrease capillary permeability and fragility. This effect contributes to decreased permeability of the blood-brain barrier (increased blood-brain permeability has been linked to autoimmune diseases of the central nervous system, schizophrenia, "cerebral allergies," and a variety of other psychiatric disorders), helps maintaining the brain¡¯s protection from drugs and naturally occurring degradation products by inhibiting both enzymatic and nonenzymatic degradation of the basement membrane collagen of brain capillaries.

2. Vascular disorders

Considered to be the result of its normalization effect in capillary permeability, bilberry Anthocyanosides has been used in the treatment of capillary fragility, blood purpuras, various circulation disturbances of the brain (similar to that of Ginkgo Biloba), venous insufficiency, varicose veins, and microscopic blood loss in the urine caused by kidney capillary fragility (capillary leakage).

3. Eye Disorders

Bilberry extracts appear to offer significant benefit to the eyes, presumably via an ability to improve the delivery of oxygen and blood to the eye. The origin of many eye diseases including cataract formation and macular degeneration is ultimately related to damage caused by free radicals to the eyes. Bilberry extract as a powerful antioxidant, protects the eyes from these free radical damages.

1) Cataracts

In one human study, bilberry extract stopped progression of cataract formation in 97 percent of fifty patients with senile cortical cataracts.

2) Macular degeneration

Bilberry anthocyanosides may offer significant protection against the development of macular degeneration. In one study, thirty-one patients with various types of retinopathy (twenty with diabetic retinopathy, five with retinitis pigmentosa, four with macular degeneration, and two with hemorrhagic retinopathy due to anticoagulant therapy) were treated with bilberry extract. A tendency toward reduced permeability and a tendency to hemorrhage were observed in all patients, especially those with diabetic retinopathy.

3) Glaucoma

Bilberry extract may also play a significant role in the prevention and treatment of glaucoma via its effect on collagen structure of the eyes. In the eyes, collagen provides tensile strength and integrity to the tissues.

4. Vision Improvement

Scientific studies showed that the administration of bilberry extract to healthy subjects resulted in improved nighttime visual acuity, quicker adjustment to darkness, and faster restoration of visual acuity after exposure to glare. Further studies confirmed these results. Results were most impressive in individuals with retinitis pigmentosa and hemeralopia (day blindness - an inability to see as distinctly in bright light as in dim light).

5. Effect on Platelets

Excessive platelet aggregation is linked to atherosclerosis and blood clot formation. Anthocyanosides, like many other flavonoids, have been shown to exert significant antiaggregation effects on platelets.

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Certificate Of Analysis

Item	Standard	Results
Appearance	Deep purple powder	Complies
Taste	Acerbity and sweet	Complies
Anthocyanosides	>=110%	12%
Loss on drying	<5.0%	4.0%
Ash:	<5.0%	3.5%
Total Count	<1000/G	10
Yeast&Mould	<10/G	Negative
Salmonella	Negative	Negative
E.coli	Negative	Negative

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