Status: ISO 1750 (published)
IUPAC: 2′,5-dichloro-4′-nitrosalicylanilide
CAS: 50-65-7
Formula: C13H8Cl2N2O4
Activity: molluscicides
Notes: The name “clonitralid” is used in Germany.
When this substance is used as an ester or a salt, its identity should be stated, for example niclosamide-olamine [1420-04-8].

Structure:

niclosamide-olamine
Mol. wt. 388.2 M.f. C15H15Cl2N3O5 Form Yellow, crystalline solid. M.p. Decomposes at 208 ºC V.p. <<1 mPa (20 °C) Solubility In water 0.1 g/l (20 ºC). In n-hexane, toluene <0.1, dichloromethane 0.015, isopropanol 0.25 (all in g/l, 20 ºC).

Niclosamide APPLICATIONS
Mode of action Molluscicide with respiratory and stomach action. Uses Control of golden apple snail in rice. Control of schistosomiasis and fascioliasis in man by killing fresh-water snails which act as intermediate hosts. Also used for veterinary control of tapeworm infestations. Formulation types EC.

Niclosamide ANALYSIS
Product analysis by redox titration (WHO Specifications Pesticicides Used in Public Health, p. 309). Residues in water measured by colorimetry (R. Strufe, Pflanzenschutz-Nachr. (Engl. Ed.), 1962, 15, 42) or by titration (details from Bayer AG).